রবিবার, ৩০ সেপ্টেম্বর, ২০১২

Maria Shriver: FURIOUS With Arnold Schwarzenegger, 60 Minutes

Source:

florida debate rand paul mark kirk florida gop debate freddie mac kristin cavallari jay cutler

Common Anxiety Drugs Can Increase Dementia Risk in Baby ...

Patients over the age of 65 who begin taking benzodiazepine (a popular drug used to treat anxiety and insomnia) are at an approximately 50% increased risk of developing dementia within 15 years compared to those who never use the drug.


Alzheimer's Reading Room If you are a baby boomer, or over the age of 65, you will want to read the summary of research published below.

Benzodiazepines are a class of psychoactive drugs . They are commonly used to treat anxiety and insomnia.

Benzodiazepines comprise a large family of medications,

Some of those more commonly prescribed include:


These drugs are among the highest selling drugs in the marketplace.
Subscribe to the Alzheimer's Reading Room

Over 65s at increased risk of developing dementia with benzodiazepine


Patients over the age of 65 who begin taking benzodiazepine (a popular drug used to treat anxiety and insomnia) are at an approximately 50% increased risk of developing dementia within 15 years compared to never-users, a study published today on bmj.com suggests.

The authors say that "considering the extent to which benzodiazepines are prescribed and the number of potential adverse effects indiscriminate widespread use should be cautioned against".

Benzodiazepine is a widely prescribed drug for the over 65s in many countries: 30% of this age group in France, 20% in Canada and Spain, 15% in Australia. Although less widespread in the UK and US it is still very widely used and many individuals take this drug for years despite guidelines suggesting it should be limited to a few weeks. Previous studies have found an increased risk of dementia, but others have been non-conclusive.

Researchers from France therefore carried out a study on 1063 men and women (average age 78) in France who were all free of dementia at the start. The study started in 1987 and follow-up was 20 years. The researchers used the first 5 years to identifying the factors leading to benzodiazepine initiation and evaluated then the association between new use of this drug and the development of dementia. They also assessed the association between further benzodiazepine initiation during the follow-up period and risk of subsequent dementia. Rates were adjusted for many factors potentially affecting dementia, such as age, gender, educational level, marital status, wine consumption, diabetes, high blood pressure, cognitive decline, and depressive symptoms.

95 out of the 1063 patients started taking benzodiazepine during the study. 253 (23.8%) cases of dementia were confirmed, 30 in benzodiazepine users and 223 in non-users. New initiation of the drug was associated with shorter dementia-free survival.

In absolute numbers, the chance of dementia occurring was 4.8 per 100 person years in the exposed group compared to 3.2 per 100 person years in the non-exposed group. A "person year" is a statistical measure representing one person at risk of development of a disease during a period of one year.

The authors say that although benzodiazepine remains useful for treating anxiety and insomnia, there is increasing evidence that its use may induce adverse outcomes in the elderly such as serious falls and fall-related fractures and this study may add dementia to the list. They say that their data add to the accumulating evidence that the use of benzodiazepines is associated with increased risk of dementia and, if true, that this "would constitute a substantial public health concern". Therefore, taken the evidence of potential adverse effects into account, physicians should assess expected benefits, limit prescriptions to a few weeks, and uncontrolled use should be cautioned against. They conclude that further research should "explore whether use of benzodiazepine in those under 65 is also associated with increased risk of dementia and that mechanisms need to be explored explaining the association"


The Alzheimer's Reading Room (ARR) offers a searchable Knowledge Base that contains over 3,800 articles about Alzheimer's disease. This intellectual capital is offered free of charge and is available to the entire Alzheimer's community Worldwide via the ARR website. Print Friendly and PDF

Source: http://www.alzheimersreadingroom.com/2012/09/common-anxiety-drugs-can-increase.html

johan santana viktor bout ncaa hockey role models ferdinand porsche gregg williams theraflu

শনিবার, ২৯ সেপ্টেম্বর, ২০১২

Motivational Music For Self Development: Let's Go! (Performed by ...

Great motivational music that inspires one to overcome one of the greatest hindrances to self development; Procrastination. Check it out?

This is verb music.

Later.

-Heard

P.S. Download links to be added later.

Source: http://www.verbmusic.com/motivational-music-for-self-development-lets-go-performed-by-calvin-harris-featuring-ne-yo/

leigh espn greg oden st patricks day st. bonaventure ira glass march madness

Little Big Town ?Tornado? Album Review

Little Big Town ?Tornado? Album Review

?Pavement Ends? is a countrified song and if you haven?t lived in the country you may not get it. Living in Southern California again?I get it. Gotta get out of town and have some fun in mother nature with your friends. This song has a ton of country twang to it and it gets the album off to a great start. I dare you not to bob your head or stomp your feet to this song. Seriously try. You can?t. Fun song. Great song.

?Pontoon? is a song that makes me want to get a house boat for the weekend with some friends or may e a pontoon. This song has pep and is a very happy feel good song. The bass line jams an the drums are poppy. The lyrics are light and catchy. You can?t help but sing along. It?s a great summer time hit and should bring back some great memories for you like it does for me. I?ve heard it 5 times so far today on the radio. It?s great. Love it.

?Sober? is a love song about loving being in love and drunk on love. This is a cool song. It?s not slow nor is it fast. It has a nice pace to it and the message rings out loud and clear. ?When I die I don?t want to die sober? No one wants to die lonely. I agree. I don?t anyway. ?I love being in love. It?s the best kind of drug.? Yes it is. Such pretty harmonies. This is such a pretty song. I love it. Great song.

?Front Porch Thing? is going to get rid of your country blues with some good ole southern rock country blues. This song fucking rocks! ?Having so much Fun in outa be a sin!? I want to go jam with these guys on their porch. Sounds like a great time as the guitar licks ring out the song ends. I want more! That must be a great live song. Love it. Great song. Radio time. Next please.

?Your Side of the Bed? is sad song. Nothing worse than being with the one you love and knowing that you are a million miles apart. Lying still in the deafening silence of a dying love. Beautiful song. I feel really depressed and completely alone. LONELY It did it?s job. Great song.

?Leavin? in Your Eyes? is a sight no one wants to see. This is country and it has to be sung. This song has great music behind it. It is very poppy. It is a good song but not grabbing a hold of me like the rest of the album has done. Great harmonies and it is musically great, but I?m not feeling it. Good song.

?Tornado? is a song about a woman tearing a man?s heart to pieces and destroy him because she can. Something about women scorned. Pretty sure I?ve covered that in another review. The destructive force that is woman. Stop pissing them off guys?..And can you ladies not take out your rage on the few good guys out there. They are not the ones that broke your heart. ?I?m a tornado. Looking for a man to break.? Ruthless! I?m not saying some guys don?t deserve it. They do. This should be on the radio in the next few months. Boot on you heart stomping boots girls and let?s ride. Good song.

?On Fire Tonight? is an upbeat fun song that gets the blood pumping. Getting back to having a good time and letting go of all the troubles the world piles on your shoulders. The guitar is rocking and the band is jamming. The lyrics are catchy and ?Be on Fire tonight? yes we are. Let?s burn this baby down. Barn burner for sure. Great song.

?Can?t Go Back? is a look back at the things we wish we could change. Gorgeous harmonies. ?I don?t want to see this house not be a home. I don?t want to witness the end of you and me.? Very mellow song. We can not fix our mistakes and let the important moments in our lives slip away. Live in the now and love while you can. Tell them you love them every chance you get. You never know when it?s your last breath. Good Song.

?Self Made? is about self confidence and making the world around you the world you want it to be. Relying on others will never help you reach your dreams. Dream Big. Do Big. Be Big. The success of the self made person is far more rewarding than anything handed to you. Fun upbeat song with a positive message. Of course I love it. Great song.

?Night Owl? is a good song to grab your girl and slow dance to. Wishing that a night owl is waiting up for you? Me too. This is a pretty song and a nice finish to the album. You can feel the love in this song. ?I hope you?re not asleep when I get there.?

You are gonna go through this album like a Tornado. It moves fast and is built for speed. Every song is made radio ready by Little Big Town. Short and to the point. I can easily hear any of these songs on the radio today. Man can they sing. Wow! Seriously?.as a song writer I am in awe of them. They make it seem effortless. The album is a mix of slow sad songs with life lessons and fast live your life with lots of love songs. Everything you expect from a country album. Although, I would like some fiddle in here but that?s just me; but someone should buy the band a beer cause they are rocking. There are some really great songs in here and Little Big Town has a big sound with an even bigger heart. I?m sure there is a little town out there proud of their homegrown stars. This is a good album for your Country Music collection and I for one need to catch Little Big Town in concert soon.

GRADE: B

K.C. Murdock
Executive Producer

?
This blog is energized and brought to you by:

?

?

?

?

Source: http://www.downtheroadshow.com/little-big-town-tornado-album-review-2012-09-28/?utm_source=rss&utm_medium=rss&utm_campaign=little-big-town-tornado-album-review

torrey smith sofia vergara oakland raiders Jessica Lange houston texans houston texans NFL scores week 3

Showcase Listing! 3916 W Roanoke Street, Broken Arrow, OK 74011

This home is in desirable Nottingham Subdivision, located south of 101st Street and west of 129th East Avenue.

From the moment you park your car in front of the awesome 3-car garage and walk past the lovely, landscaped entry to open the door, this spacious home beckons.? The golden oak hardwoods and French doors sing ?welcome? as you step inside.

Many splendid features make this a terrific home for entertaining friends or family!

Imagine?preparing a feast for your guests or baking cookies with the kids in a kitchen complimented by golden oak cabinetry, special lighting effects, generous pantry closets and ample counter space.? Dine in the generous breakfast area, or add elegance to the simplest meal as you dim the lights beneath the domed ceiling and take your place at the dining room table.

Take in the natural accents of the great room offered by tiled fireplace, grand oak-trimmed staircase and high ceilings or add your own special touches.

Relax on the covered patio or 2nd floor deck while the in-ground sprinklers water the yard.? If you?re not up for quiet time, you can take advantage of the huge, privacy-fenced back yard for gardening or playtime.? Take advantage of the community park, playground or swimming pool for a quick getaway, or take a walk through the neighborhood and visit with your favorite neighbors for a change of pace!? Stuck inside on a rainy day?? Select a game from the wall of oak cabinetry in the game room, have some snacks and a drink at the wet-bar, and enjoy.

As your day comes to an end, toss the dirty clothes into the laundry and step around the corner to wind-down midst the amenities of your 1st floor master suite . . . double-bowl oak vanity, spa tub, shower and large walk-in closet.??No worries, only sweet dreams as your head hits the pillow?. . .?new paint and carpet/padding throughout in July 2012 . . . . . .

Just imagine . . .

Sound like the lifestyle you?re looking for?? To schedule a private viewing, just scroll down, click the schedule a showing button and let us know when!

3916 W Roanoke Street, Broken Arrow, OK 74011 (MLS # 1223400)

(all data current as of 9/28/2012)
Price $272,000
Beds 4
Baths 2 full, 1 half
Home size 3,088 sq ft
Lot Size n/a
Days on Market 59
JUST FINSIHED 15K REPAIRS/IMPROVEMENTS. SOLD IN AS-IS CONDITION

Property Type(s): Residential, Single Family

Last Updated 9/20/2012 Tract n/a
Year Built 1999 Community Nottingham
Garage Spaces 3.0 County Tulsa
Total Parking 3

Schools

School District Broken Arrow (3)
Grade School Wolf Creek
Jr. High School Oliver
High School Broken Arrow/S.

Additional Details

Features

# Fireplaces 1
Additional Buildings None
Exterior Features None
Exterior Siding Full Brick
Fence Full, Privacy
Garage Capacity 3
HOA Mandatory Yes
Interior Features 9+ Ceilings
Lot Description None
Pool on Premises None
Property Sub Type House
Style Other

Location

Listing information deemed reliable but not guaranteed. Read full disclaimer.

Listed with Prudential/Detrick Realty

(view all details for MLS #1223400)

Source: http://tulsa.pruhomequest.com/blog/showcase-listing-3916-w-roanoke-street-broken-arrow-ok-74011/

isiah thomas passover easter recipes live free or die hard carlos pena amanda bynes arrested f 18

শুক্রবার, ২৮ সেপ্টেম্বর, ২০১২

Compelling Ideas at the UN: Energy, Health, Education and ...

| By WorldBankBlogs

UNITED NATIONS | It has been a week of inspiring ideas and action plans at the United Nations General Assembly in New York. I met with a number of world leaders, including Liberian President Ellen Johnson Sirleaf. We talked about the importance of creating jobs for ex-combatants, the pressing need for more energy sources, and more. You can hear my thoughts on our meeting in the video below. Video Platform Video Management Video Solutions Video Player read more

Excerpt from?-?

Compelling Ideas at the UN: Energy, Health, Education and #whatwillittake

Related posts:

  1. Nuclear Energy After Fukushima
  2. Jordan Converts Waste to Energy
  3. WECalc, Your Home Water-Energy-Climate Calculator
  4. SharedSolar: Mobiles and Micro-Grids For More Efficient Energy
  5. Energy and Monkeypox
Posted by WorldBankBlogs on Sep 28 2012. Filed under Aid & Development. You can follow any responses to this entry through the RSS 2.0. You can leave a response or trackback to this entry

Source: http://www.globalhealthhub.org/2012/09/28/compelling-ideas-at-the-un-energy-health-education-and-whatwillittake/

quirky chrissy teigen chia seeds embers shannon brown mike rowe shld

Investing In The Philippines: Escape The U.S. With A Low-Debt, Low ...

Money Morning Staff:?Along with its various countries and economies, the Asian investment thesis has certainly evolved over the years.?

Those born in the 1960s and 1970s surely remember the 1980s when Japan?s economy rose to global prominence, showing the world that at least at that time, Japan truly was the land of the rising sun.

The Asian financial crisis struck in the late 1990s, but that even only temporarily chased Western investors away from the continent. Caution would give way to ebullience earlier this century as investors became enamored by the Chinese and Indian growth stories.

The Euro?s Demise Has Been Set in Motion: Are you protected?


"Nationalism will emerge. Healthier countries will not see fit to spend their hard earned money to bail out their less responsible neighbors."

CLICK HERE to get your Free E-Book, ?Why It?s Curtains for the Euro?

Flush with statistics about that pair representing two of the fastest growing economies in the world and that one or both would one day pass the U.S. in terms of economic heft, investors were once again seduced by Asian opportunities.

Renewed appetite for Asian exposure coincided with another boom, that of the exchange-traded fund (ETF) industry. As the Chinese and Indian economies became juggernauts, ETF sponsors have met investor demand for exposure to these countries coming up with everything from ETFs focused on Chinese technology companies to Indian small-caps.

ETF issuers did not stop there. As investors clamored for ways to access other Asian markets, ETF sponsors obliged.

In other words, the Chinese and Indian growth stories gave way to the burgeoning economies of Indonesia, Thailand and others. Since the March 2009 market bottom, the iShares MSCI Thailand Investable Market Index Fund (NYSEARCA:THD) and the Market Vectors Indonesia ETF (NYSEARCA:IDX) have been two of the best performing ETFs of any kind.

Those funds are still performing well, but a case can be made there is a new sheriff on the Asian investment block.

Investing in Philippines

EPHE: More to the Story?The Philippines, a Southeast Asian nation comprised of thousands of islands, is not completely unknown to Western investors, but the economy there is smaller comparable nations such as Indonesia, Malaysia and Thailand.

A fair assessment might be to say the country is just starting to shed its under-the-radar status.

That much is proven by the iShares MSCI Philippines Investable Market Index Fund (NYSEARCA:EPHE), almost certainly the best way for U.S. investors to tap into the Philippine investment thesis without incurring unnecessary single stock risk.

Actually, there are not many Philippine American depositary receipts available, so EPHE is the best way to access the Philippines. Period.

EPHE debuted two years ago and now has over $101 million in assets under management, a sum that indicates investors have at least been intrigued by what the Philippines has to offer.

Those investors have not been disappointed.

EPHE is up 28.5% year-to-date, making it one of the best funds tracking?any?individual country in?any?region of the world.

EPHE?s performance does not paint the entire picture about the Philippine economy.

Arguably, when the various statistics are weighed together, one might wonder why the ETF has not performed even better and why allegedly smart economists and institutional investors are not embracing the Philippines to a larger extent.

Inflation is benign in the Philippines. That is something India cannot say.

Even Thailand has struggled with rising prices at various points in recent years. The Philippines could notch GDP growth of 6% this year and the country is well on its way to meeting or exceeding that number after posting growth of 6.1% in the first half of the year.

Then there is a fact about the Philippines that would make many Americans and Europeans gasp in disbelief: The country could be debt-free in a few years.

Currently sitting on a debt-to-GDP ratio of 50%, one the U.S., Japan and the Eurozone would die for, government spending is less than 19% of GDP.

Buoyed by $76 billion in international reserves, the Philippines? external balance sheet is nothing short of impressive. Standard & Poor?s, the ratings agency that is notoriously slow on the uptake, still has a junk?credit?rating on the Philippines, though it is BB+, the highest non-investment grade rating. S&P upgraded the Philippines in July and the country?s BB+ rating is its highest since 2003.

Adding to the bull case for the Philippines is a favorable slate of country rankings. Data from the Heritage Foundation indicate that when metrics such as economic freedom, freedom from corruption, land freedom and related metrics are combined, the Philippines scores better than other Southeast Asian economies such as Indonesia and Vietnam. The Philippines also tops Greece,?China, India and Russia.

Note to investors: One or two nice statistics here or there do not mean any country?s investment thesis is perfect, the Philippines included, so don?t throw all your money into EPHE.

The country has strides to make on the corruption front, corporate legal reform is essential and the country?s rate of poverty is high, even for a developing nation. Those factors should not be ignored, but the totality of the Philippines economic story indicates its (EPHE?s) best chapters have yet to be written.

Written By The Money Morning Staff

We?re in the midst of the greatest investing boom in almost 60 years. And rest assured ? this boom is not about to end anytime soon. You see, the flattening of the world continues to spawn new markets worth trillions of dollars; new customers that measure in the billions; an insatiable global demand for basic resources that?s growing exponentially; and a technological revolution even in the most distant markets on the planet.And Money Morning is here to help investors profit handsomely on this seismic shift in the global economy. In fact, we believe this is where the only real fortunes will be made in the months and years to come.

NYSE:EPHE, NYSE:IDX, NYSE:THD

Source: http://etfdailynews.com/2012/09/28/investing-in-the-philippines-escape-the-u-s-with-a-low-debt-low-inflation-economy-idx-thd-ephe/

iman shumpert mayweather vs cotto shumpert hopkins hopkins dear john derrick rose torn acl

বৃহস্পতিবার, ২৭ সেপ্টেম্বর, ২০১২

Astronauts may play role in Mars robotic missions

'},"otherParams":{"t_e":1,".intl":"US"},"events":{"fetch":{lv:2,"sp":"7665149","ps":"LREC,MON","npv":true,"bg":"#FFFFFF","em":escape('{"site-attribute":"_id=\'2c44d470-7832-31e4-9def-9309925b41d3\' sensitivity=\'0\' rs=\'lmsid:a097000000MqtFvAAJ\' ctype=\'fn_news;News\' ctopid=\'1720500;2299500;1996000;1484489;1985000;1542500;1483989;1035500;1480989\' can_suppress_ugc=\'1\' content=\'no_expandable;ajax_cert_expandable;\' ADSSA"}'),"em_orig":escape('{"site-attribute":"_id=\'2c44d470-7832-31e4-9def-9309925b41d3\' sensitivity=\'0\' rs=\'lmsid:a097000000MqtFvAAJ\' ctype=\'fn_news;News\' ctopid=\'1720500;2299500;1996000;1484489;1985000;1542500;1483989;1035500;1480989\' can_suppress_ugc=\'1\' content=\'no_expandable;ajax_cert_expandable;\' ADSSA"}')}}};var _createNodes=function(){var nIds=_conf.nodeIds;for(var i in nIds){var nId=nIds[i];var dId=_conf.destinationMap[nIds[i].replace("yom-","")];n=Y.one("#"+nId);if(n)var center=n.one("center");var node=Y.one("#"+dId);var nodeHTML;if(center && !node){nodeHTML=_conf.nodes[nId];center.insert(nodeHTML);};};};var _prepareNodes=function(){var nIds=_conf.nodeIds;for(var i in nIds){var nId=nIds[i];var dId=_conf.destinationMap[nIds[i].replace("yom-ad-","")];n=Y.one("#"+nId);if(n)var center=n.one("center");var node=Y.one("#"+dId);if(center && node){center.set("innerHTML","");center.insert(node);node.setStyle("display","block");};};};var _darla;var _config=function(){if(YAHOO.ads.darla){_darla = YAHOO.ads.darla;_createNodes();};};var _fetch=function(spaceid,adssa,ps){ if (typeof(ps)!='undefined') _conf.events.fetch.ps = ps;if(typeof spaceid != "undefined") _conf.events.fetch.sp=spaceid;adssa = (typeof adssa != "undefined" && adssa != null) ? escape(adssa.replace(/\"/g, "'")) : "";_conf.events.fetch.em=_conf.events.fetch.em_orig.replace("ADSSA", adssa);if(_darla){_prepareNodes();_darla.setConfig(_conf);_darla.event("fetch");};};Y.on("domready", function(){_config();});;var that={"fetch":_fetch,"getNodes":_conf.nodes,"getConf":_conf};return that;}();/* Backwards compatibility - Assigning the latest instance to the main fetch function */YUI.PhotoAdsDarla.fetch=YUI.PhotoAdsDarla.photoslightboxdarla.fetch; }); Y.later(10, this, function() {YAHOO.namespace('Media.Social').Lightbox = {}; }); Y.later(10, this, function() {Y.Media.Article.init(); }); Y.later(10, this, function() {new Y.Media.AuthorBadge(); }); Y.later(10, this, function() {new Y.Media.Branding(); }); Y.later(10, this, function() {Y.on("load", function () { YUI.namespace("Media.SocialButtons"); var instances = YUI.Media.SocialButtons.instances || [], globalConf = YAHOO.Media.SocialButtons.conf || {}, vplContainers = []; Y.all(".ymsb").each(function (node) { var id = node.get("id"), conf = YAHOO.Media.SocialButtons.configs[id], instance; if (conf) { instance = new Y.SocialButtons({ srcNode: node, config: Y.merge(globalConf, conf.config || {}), contentMetadata: conf.content || {}, tracking: conf.tracking || {} }); vplContainers.push( { selector: "#" + id, callback: function(node) { instance.render(); instance = conf = id = null; } }); if (conf.config && conf.config.dynamic) { instances.push(instance); } } }); Y.Global.Media.ViewportLoader.addContainers(vplContainers); YUI.Media.SocialButtons.instances = instances; }); }); Y.later(10, this, function() {if(Y.Photos && Y.Photos.LightboxModule) { var lightboxabed6c9352b4af351622416e4df32127 = new Y.Photos.LightboxModule('{"spaceid":"7665149","ult_pt":"story-lightbox","darla_id":"","images_total":0,"xhr_url":"/_xhr/related-article/lightbox/?id=2c44d470-7832-31e4-9def-9309925b41d3","xhr_count":20,"autoplay_if_first_item_is_video":true}',[],[]); } if(Y.Photos && Y.Photos.LightboxModule) { var lightbox4f2d54f75bb594a4a8a6d60aab699449 = new Y.Photos.LightboxModule('{"ss_uuid":"9aa1c5fd-7090-34fc-80dd-b2d3c150dad1","spaceid":"7665149","darla_id":"","images_total":0}',[],[]); if (lightbox4f2d54f75bb594a4a8a6d60aab699449.checksupport() !== false) { var lightbox_div = Y.one('.lightbox4f2d54f75bb594a4a8a6d60aab699449'); if (lightbox_div !== null) { lightbox_div.on('click', function(e) { e.preventDefault(); lightbox4f2d54f75bb594a4a8a6d60aab699449.slideShow(e); }); } } } }); Y.later(10, this, function() {YUI.namespace("Media.Article.Lead"); YUI.Media.Article.Lead.config = { playerUrl : 'http://d.yimg.com/nl/ynews/site/player.swf', autoPlay : 0 }; }); Y.later(10, this, function() {new Y.Media.RelatedArticle({count:"2",start:"1", mod_total:"10", total:"1", content_id:"2c44d470-7832-31e4-9def-9309925b41d3", spaceid:"7665149", related_count:"-1" }); }); Y.later(10, this, function() {(function(d){ d.getElementsByTagName('head')[0].appendChild(d.createElement('script')).src='http://d.yimg.com/oq/js/csc_news-en-US-core.js'; })(document); }); Y.later(10, this, function() {var Topstory = new Y.Media.Topstory({ 'useJapi' : '1', 'tabbedListId' : 'mediatopstorycoketemp', 'content_id' : '2c44d470-7832-31e4-9def-9309925b41d3', 'ids' : ["e732ea89-8628-43e9-b9b9-29ddad27e7e3"], 'latestList' : [0], 'argsList' : [{"storycount":"7","img_start":"","img_end":"","popup_switch":"1","provider_switch":"1","timestamp_switch":"1","max_title_length":"150","max_summary_length":"","item_template":"title_bullet","storystart":"1","list_source":"listid","categories":[]}], 'labels' : { "more" : 'More' }, 'defaultSec' : '' || 'MediaTopStoryCokeTemp', 'spaceId' : '7665149', 'pagequery' : '', 'popupswitch' : '"1"', 'more_inline' : '1', 'ads_refresh' : [], 'apply_filter' : '', 'filters' : '[]', 'queryUrl' : 'list_id={list_id}&list_source={list_source}&apply_filter={apply_filter}&filters={filters}&content_id={content_id}&categories={categories}&selected_tab={selected_tab}&relatedcollections_index={relatedcollections_index}&latest_on={latest_on}&s=7665149&sec={sec}&pagequery={pagequery}&story_start={story_start}&storycount={storycount}&img_start={img_start}&img_end={img_end}&popup_switch={popup_switch}&provider_switch={provider_switch}&author_switch={author_switch}&timestamp_switch={timestamp_switch}&max_title_length={max_title_length}&max_summary_length={max_summary_length}&item_template={item_template}&more_inline={more_inline}&base_start={base_start}&cache_ttl=TTL_LEVEL_30', 'enableSC' : '0' }); Topstory.init(); }); Y.later(10, this, function() { if(!("Media" in YAHOO)){YAHOO.Media = {};} if(!("ugcrate" in YAHOO.Media)){YAHOO.Media.ugcrate = {};} if(!("Media" in Y)){Y.namespace("Media");} YAHOO.Media.ugcrate.ratings_0871070b2be46414f1d45facc42ff4b5 = new Y.Media.UgcRate({"context_id":"4d1e6261-ddb7-48dc-8f56-119775da5764","sCrumb":"","containerId":"yom-sentimentrate-0871070b2be46414f1d45facc42ff4b5","rateDimensions":"d1","appLang":"en-US","sUltSId":"7665149","sUltProperty":"news-en-US","sUltCampaign":"","sUltPlatform":"ugcwidgets","sUltIntl":"US","sUltLang":"en-US","selfPageUrl":"http:\/\/news.yahoo.com\/astronauts-may-play-role-mars-robotic-missions-215919934.html?_esi=0","artContentId":"2c44d470-7832-31e4-9def-9309925b41d3","sUltQstnTxt":"How much time do you spend playing games on your mobile devices?","artContentTitle":"Astronauts may play role in Mars robotic missions","artContentDesc":"NASA\\'s future plans to explore Mars may end up using astronauts as space messengers.","sUltBucketId":"test1","sUltSection":"sentirating","sUltBeaconUrl":"","sUltRecordPageviews":"1","sUltBeaconEnable":"1","serviceUrl":"\/_xhr","publisherContextId":"","propertyId":"2fcd79b5-b3a3-333e-b98e-722536a6698f","configurationId":"435db9ee-c55e-3766-b20d-c8ad3ff889d1","graphId":"","labelLeft":"Don\\'t usually play games","labelRight":"Far too much!","labelMiddle":"","itemimg":"http:\/\/l.yimg.com\/a\/i\/ww\/met\/yahoo_logo_us_061509.png","selfURI":"","aggregateRatingCount":"5397","aggregateReviewCount":"0","leftBlocksNum":"4815","rightBlocksNum":"579","leftBlocksPerCent":"89","rightBlocksPerCent":"11","ugcrate_apihost":"api01-us.ugcl.yahoo.com:4080","publisher_id":"news-en-US","yca_cert":"yahoo.ugccloud.app.trusted_proxies","timeout_write":"5000","through_proxy":"false","optionStats":"{\"s1\":2894,\"s2\":593,\"s3\":436,\"s4\":472,\"s5\":420,\"s6\":579,\"s7\":0,\"s8\":0,\"s9\":0,\"s10\":0}","l10N":"{\"FIRST_TO_READ\":\"You are first to read this. Share your feelings and start a conversation.\",\"SHARE_YOUR_FEELINGS\":\"You too can share your feelings and start a conversation!\",\"HOW_YOUR_FRIENDS_THINK\":\"Thank you for sharing your feeling on this article!\",\"PRE_SHARE_MSG\":\"Your Facebook friends on Yahoo! can see how you responded to this question. To share your response on Facebook, click on the Facebook share option.\",\"START_THE_CONVERSATION\":\"Start the Conversation\",\"THANKS_FOR_SHARING\":\"Sure, that's how you feel... But what do your friends think?\",\"POLL_HEADER\":\"SOCIAL SENTIMENT\",\"SERVER_ERROR\":\"Oops there seems to be some error, please try again later\",\"LOADING\":\"Loading...\",\"SHARE_AFTER_COMMENT\":\"Your response has been shared on Facebook.\",\"UNDO\":\"Undo\",\"UNIT_PEOPLE\":\"People\",\"NUM_PEOPLE_DISAGREE\":\"disagree with your opinion.\",\"READ_MORE_TEXT\":\"Read what they have to say.\",\"SLIDER_THUMB_WORDING_BEFORE_VOTING\":\"WHAT DO YOU THINK?\",\"SLIDER_THUMB_WORDING_VERB_BEFORE_VOTING\":\"DRAG\",\"SLIDER_THUMB_WORDING_THANKS_VOTING\":\"Thanks for voting\",\"NUM_PEOPLE_ANSWERED\":\" 5,397 people have answered this question\",\"ONE_PERSON_ANSWERED\":\" 1 person has answered this question\",\"TWO_PEOPLE_ANSWERED\":\" 2 people have answered this question\",\"NUM_PEOPLE_RATED__s1\":2894,\"NUM_PEOPLE_RATED__s2\":593,\"NUM_PEOPLE_RATED__s3\":436,\"NUM_PEOPLE_RATED__s4\":472,\"NUM_PEOPLE_RATED__s5\":420,\"NUM_PEOPLE_RATED__s6\":579,\"NUM_PEOPLE_RATED__s7\":0,\"NUM_PEOPLE_RATED__s8\":0,\"NUM_PEOPLE_RATED__s9\":0,\"NUM_PEOPLE_RATED__s10\":0}","fbconfig":"{\"message\":\"undefined\",\"name\":\"undefined\",\"link\":\"\",\"source\":\"\",\"picture\":\"http:\\\/\\\/l.yimg.com\\\/a\\\/i\\\/ww\\\/news\\\/2011\\\/09\\\/27\\\/yahoo-tc.jpg\",\"description\":\"\",\"captionLeft\":\"undefined\",\"captionRight\":\"undefined\",\"app_id\":\"196660913708276\",\"redirect_uri\":\"\\\/_xhr\\\/ugcratefbredirect\\\/\"}","template_id":"LONG_SLIDER_SOUTH","obj_id":"ratings_0871070b2be46414f1d45facc42ff4b5","opt_count":"6","opt_color1":"","opt_color2":"","template_html":"

Source: http://news.yahoo.com/astronauts-may-play-role-mars-robotic-missions-215919934.html

bret michaels pekingese tcu football westminster bonnaroo 2012 lineup twisted metal sea lion

Term Papers Academic Writing - Just Articles Article Directory

Article by Kelvin Brown

In academics, academic writing is a major assignment. In academic writing, one is supposed to possess the necessary academic writing skills. There are various academic writings and these include term papers academic writing, dissertation academic writing and essay academic writing and academic paper writing. Often, students are assigned academic writing that is hard to complete effectively. If you have problems doing your academic writing, seek for academic writing assistance. However make sure that you approach the right company since there are many online academic writing companies who claim to provide you with good custom academic writing but they do not. Contact us. We offer academic writing help to many students all over the world. Our academic writing company is trusted by many students because of the quality of our academic writing services. We offer online academic writing. You therefore do not have to come to our offices. Make your academic writing order from any place and we will also give you the feedback online. You only need to go to our website and place your order. We have professional academic writers. We employ the services of PhD, doctorate and masters academic writers. You are hence assured that your academic papers writing will be handled by a professional. Our writers are well trained in all styles of academic writing. Do not be worried if your professor has specified the use of a writing style that you are not sure of its standards. Buy academic writing in APA, Vancouver, MLA and any other writing style. Order to buy custom academic writing on any topic regardless of your level of study. we only assign your academic writing order to an academic writer of your study level. Our writers write quality academic writing on any subject. Buy sociology academic writing, biology academic and academic writing on any other subject. All our academic writings for sale are well researched on and written following all the requirements and instructions of our customer. We assure you that when you come to us with your request on write my academic writing, we will write you a non plagiarized academic writing. We have always kept in mind that students are penalized and even punished for presenting plagiarized academic writing. That is why we always ensure that your academic life is secured. We offer affordable academic writing services. We never overcharge our clients but only ensure that you pay for the quality that you receive. Once you purchase academic writing from us, you will never go anywhere else. We also give students academic writing tips and guidelines. There are those students who want to do their academic writing but do not know how to go about the whole processes. That is why we help them with academic writing tips since academic writing also enhances the writer?s writing skills. Our academic writers follow all the rules and standards of academic writing in doing the custom academic writing for you. Here, we ensure that we write you academic papers that will enable you get the best grades. Buy academic writing now and come to us with all your academic writing needs in future. Your custom academic writing is edited well to ensure that it carries no mistakes in spelling, grammar and formatting. Do not go anywhere else, buy from us and get an excellently done academic writing.

About the Author

Author is associated with AcademicWritingTips.org which is a global Custom Essay Writing and Term Paper Writing Company. If you would like help in Research Papers and Term Paper Help you can visit Academic Writing

Use and distribution of this article is subject to our Publisher Guidelines
whereby the original author?s information and copyright must be included.

Author is associated with AcademicWritingTips.org which is a global Custom Essay Writing and Term Paper Writing Company. If you would like help in Research Papers and Term Paper Help you can visit Academic Writing












Use and distribution of this article is subject to our Publisher Guidelines
whereby the original author?s information and copyright must be included.

Description: Children?s Writing and Scottish Theatre (2.58 KB) ? 3 minutes 34 seconds 4. Writing Good Ome?More Description: Children?s Writing and Scottish Theatre (2.58 KB) ? 3 minutes 34 seconds 4. Writing Good Omens with Terry Pratchett (3.94 KB) ? 5 minutes 32 seconds 5. Advice for aspiring writers (0.80 KB) ? 1 minute 7 seconds Read about Neil?s trip to Singapore ?
Video Rating: 4 / 5

More Writing Articles

Source: http://justarticles.net/09/term-papers-academic-writing/

toure patti smith lottery winners lottery winners april fools day pranks ohio state vs kansas daniel von bargen

বুধবার, ২৬ সেপ্টেম্বর, ২০১২

In birds' development, researchers find diversity by the peck

Tuesday, September 25, 2012
In order to observe gene expression in the developing bullfinch embryos, Mallarino and a team of Harvard undergraduate field assistants had to collect eggs from wild nests in the Dominican Republic, Barbados, and Puerto Rico. In accordance with strict fieldwork regulations, Mallarino's team collected only every third egg laid, which required them to return to the nests daily, climbing dozens of trees and cacti to carefully label every new egg. Laden with radios, notebooks, markers, heavy ladders, and a special foam crate for the delicate eggs, the team ventured into remote field sites at the crack of dawn and returned to camp before noon to incubate those they collected. Credit: Courtesy of Ricardo Mallarino

It has long been known that diversity of form and function in birds' specialized beaks is abundant. Charles Darwin famously studied the finches on the Galapagos Islands, tying the morphology (shape) of various species' beaks to the types of seeds they ate. In 2010, a team of Harvard biologists and applied mathematicians showed that Darwin's finches all actually shared the same developmental pathways, using the same gene products, controlling just size and curvature, to create 14 very different beaks.

Now, expanding that work to a less closely related group of birds, the Caribbean bullfinches, that same team at Harvard has uncovered something exciting?namely, that the molecular signals that produce those beak shapes show even more variation than is apparent on the surface. Not only can two very different beaks share the same developmental pathway, as in Darwin's finches, but two very different developmental pathways can produce exactly the same shaped beak.

"Most people assume that there's this flow of information from genes for development to an inevitable morphology," says principal investigator Arhat Abzhanov, Associate Professor of Organismic and Evolutionary Biology (OEB). "Those beaks are very highly adaptive in their shapes and sizes, and extremely important for these birds. In Darwin's finches, even one millimeter of difference in proportion or size can mean life or death during difficult times. But can we look at it from a bioengineering perspective and say that in order to generate the exact same morphological shape, you actually require the same developmental process to build it? Our latest research suggests not."

The findings have been published in the Proceedings of the National Academy of Sciences.

The Caribbean bullfinches, geographic and genetic neighbors to Darwin's finches, are a group of three similar-looking species that represent two different branches of the evolutionary tree. These bullfinches have very strong bills that are all exactly the same geometric shape but slightly different sizes.

"They specialize in seeds that no one else can touch," explains Abzhanov. "You'd actually need a pair of pliers to crack these seeds yourself; it takes 300 to 400 Newtons of force, so that's a really nice niche if you can do that. But the question is, what developmental changes must have occurred to produce a specialized beak like that?"

A new and highly rigorous genomic analysis by coauthor Kevin J. Burns, a biologist at San Diego State University, has shown that among the three Caribbean bullfinch species, this crushing type of beak actually evolved twice, independently. Convergent evolution like this is common in nature, and very familiar to biologists. But understanding that phylogeny enabled Abzhanov, lead author Ricardo Mallarino (a former Ph.D. student in OEB at the Graduate School of Arts and Sciences), and colleagues in applied mathematics at the Harvard School of Engineering and Applied Sciences (SEAS) to perform a series of mathematical and morphogenetic studies showing that the birds form those identical beaks in completely different ways. Such studies must, by their nature, be performed early in the embryonic stage of the birds' development, when the shape and tissue structure of the beak is determined by the interactions of various genes and proteins.

"In the small bullfinch you have almost a two-stage rocket system," says Abzhanov. "Cartilage takes you halfway, and then bone kicks in and delivers the beak to the right shape. Without either stage, you'll fail. In the larger bullfinches, the cartilage is not even employed, so it's like a single-stage rocket, but it's got this high-energy, synergistic interaction between two molecules that just takes the bone and drives its development straight to the right shape."

In embryos of the small bullfinch, Loxigilla noctis, the control genes used are Bmp4 and CaM, followed by TGF?IIr, ?-catenin, and Dkk3, the same combination used in Darwin's finches. Embryos of the larger bullfinches, L. violacea and L. portoricensis, use a novel combination of just Bmp4 and Ihh.

"Importantly," Abzhanov says, "despite the fact that these birds are using different systems, they end up with the same shape beak, and a different shape beak from Darwin's finches. So that reveals a surprising amount of flexibility in both the shapes and the molecular interactions that support them."

The finding offers new insight into the ways birds?the largest and most diverse group of land vertebrates?have managed to adaptively fill so many different ecological niches.

"It is possible that even if the beak shape doesn't change over time, the program that builds it does," explains Abzhanov. "For evolution, the main thing that matters for selection is what the beak actually looks like at the end, or specifically what it can do. The multiple ways to build that beak can be continually changing, provided they deliver the same results. That flexibility by itself could be a good vehicle for eventually developing novel shapes, because the developmental program is not frozen."

Following a standard process in studies of developmental biology, Abzhanov's team began with measurements of the morphological differences between species, followed by observations of gene expression in bullfinch embryos and functional experiments using chicken embryos. Along the way, mathematical models helped the team to quantify and categorize the beak shapes they were seeing.

"We used geometric morphometric analysis, looking at these beaks as curves," says coauthor Michael Brenner, Glover Professor of Applied Mathematics and Applied Physics at SEAS and Harvard College Professor. "The beak shapes would turn into contours, contours were digitized into curvatures, and curvatures were turned into representative mathematical formulas. This provided our biology colleagues with an unbiased way of determining which of the different species had beak shapes that were identical up to scaling transformations, and which were in a completely different group."

In order to observe gene expression in the developing bullfinch embryos, Mallarino and a team of undergraduate field assistants had to collect eggs from wild nests in the Dominican Republic, Barbados, and Puerto Rico. The birds breed in dome-shaped nests with small side entrances, often in the tops of tall cacti. In accordance with strict fieldwork regulations, Mallarino's team collected only every third egg laid, which required them to return to the nests daily, climbing dozens of trees and cacti to carefully label every new egg. Laden with radios, notebooks, markers, heavy ladders, and a special foam crate for the delicate eggs, the team ventured into remote field sites at the crack of dawn and returned to camp before noon to incubate those they collected.

"They're much more fragile than a chicken egg, and extremely small," says Mallarino. "We just walk very carefully."

"It's a big logistical operation," he adds. "It's five months of really, really hard work under the sun in crazy conditions, but when it works it's really rewarding. At day 6 or 7 you have a perfect, live embryo with a beak beginning to form, and you can learn so much about it."

The next step in this work is to widen the lens yet again and compare the morphological development of a broader group of birds.

"In time, hopefully we'll see how the great diversity that you see among all these highly adaptive bird beaks may actually evolve at the genetic level," says Mallarino. "That's the greater challenge."

###

Harvard University: http://www.harvard.edu

Thanks to Harvard University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 19 time(s).

Source: http://www.labspaces.net/123793/In_birds__development__researchers_find_diversity_by_the_peck

gary carter this means war bobby brown suzanne somers colbert colbert report legionnaires disease

It's All About Choices | Fireball Stocks

Can or Cannot, Will or Will Not ? Everything is a Choice

by Lou Scatigna

I was cruising around Facebook today and it seems that everywhere I turn, people are posting quotes in their statuses about choices. So I thought to myself, Lou, how can I apply this to finance to get people to think more about their financial futures and their level of commitment to their own financial literacy? Waiting for the ?AHA? moment? Ok, so here it is: If everything we do in life is a choice, good/bad, up/down, wealthy/in debt, then why can?t we just choose to be wealthy? Is there a simple answer? Maybe not; but there are some simple choices you can make to help build your financial health and lead you to that choice of building wealth.

Let?s start with something simple: how do you choose to spend your morning? Do you eat breakfast with your spouse/children and have a nice conversation? That?s great, more power to you! Do you grab something and run out the door, waving goodbye to whoever happens to be in your path? Hey, if it works for you?. Do you sit at your desk, read the paper and maybe listen to some talk radio or watch the news? OK, good choice?but is it the best choice? None of these are bad choices if they work for you, but we can go one better.

If you are the ?sit with the family and enjoy breakfast? type- great. How about adding a little conversation about the state of the family?s finances? Or maybe play a little financial game with the kids? How about getting the old newspaper out and talking about what?s going on in the world and how it affects the family, especially financially? Enjoy some conversation while teaching the kids to be more financially literate, it?ll help them learn and give you some quality time with them; not to mention keeping you up to date on your financial affairs and involving the family in the decision making. Kids learn by example, if you are interested in the economy, chances are, they will learn to be too.

Alright, you ?run out the door? types, your turn. I?m not here to judge you on your choices, but let?s see what happens if we add ten minutes onto your morning by drinking a cup of coffee and glancing over the financial section of the paper. News programs only take a few minutes to catch you up on the headlines and you can listen while getting dressed. Staying informed on what is going on in the world today makes financial sense; if you don?t know the state of the economy, how can you make decisions as a consumer? Turn on CNN when you get out of the shower. Listen to some talk radio when you are commuting to work. There are a lot of ways to keep informed without having to sit down and read the paper from cover to cover. Try something new and you might learn something about how to build your financial wealth?just from tuning in for a few minutes.

Desk jockeys, how about you? You read the paper, you listen to the news, you cruise the internet for information ? that?s great. Do you share it with your spouse?? Do you go home and talk about what you?ve learned that day? Do you ask your significant other what his/her opinion is on the economy? Do you ask for opinions on the family finances? Are you part of a team effort or are you the sole proprietor of the family finances? Conversations are important; share the wealth of knowledge that you accumulate. Take ten minutes each day to talk to your spouse about what is important to your family and how you can improve the financial future of your family. It works ? try it.

Life is full of choices. What stocks to buy, what to invest in, how much gold to own, what financial adviser to choose, how much to put in the retirement fund, how much to put aside each month for your kids? college fund.? I know sometimes it seems like the choices are out of your hands; you feel you can?t afford to save, you can?t afford to invest; there?s nothing left at the end of the month to put aside for a rainy day.? Life gets overwhelming, but if you think about the things you choose to have, but don?t necessarily need to have, you may find some wiggle room in there somewhere.? Do you really need the big, expensive house you live in or could you make do if you downsized a bit? Do you really need a new car right now? Do you need to go to the movies every weekend and then out to dinner? Do you see what I?m getting at here? Define your actual needs and differentiate from the wants in your life and you have some choices you can make.

Don?t be controlled by your feelings of material entitlement; make a choice to live a simpler life and to communicate with your spouse. Teach your kids to earn and save, not to beg and splurge as kids today tend to do.? Just about everything in life is a choice except birth and death. To quote Eleanor Roosevelt: ?In the long run, we shape our lives, and we shape ourselves. The process never ends until we die. And the choices we make are ultimately our own responsibility.? You can choose to live in a way that supports the building of wealth; the question is ? will you make that choice?

Article source: http://www.thefinancialphysician.com/blog/2012/09/its-all-about-choices-2/

Source: http://www.fireballstocks.com/2012/09/26/its-all-about-choices/?utm_source=rss&utm_medium=rss&utm_campaign=its-all-about-choices

2012 predictions new years eve ball drop new years eve times square 2012 2012 holidays prosperity japan earthquake bosom buddies

মঙ্গলবার, ২৫ সেপ্টেম্বর, ২০১২

Attempted attack on Israeli border highlights militant presence in Sinai

One soldier from the Israel Defense Forces was killed and another wounded in an attack on the Sinai border today, while three militants were killed.

By Christa Case Bryant,?Staff writer / September 21, 2012

In this August 6 file photo, Egyptian border guards patrol near the border with Israel in Rafah, Egypt.

Ahmed Gomaa/AP

Enlarge

Israel said it disrupted an attempted large-scale terrorist attack on its southern border today, underscoring the ongoing threat posed by militants in the Sinai peninsula, who have stepped up their attacks since Egypt's popular uprising last year.

Skip to next paragraph

Recent posts

' + google_ads[0].line2 + '
' + google_ads[0].line3 + '

'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "on"; google_image_size = '230x105'; google_skip = '0'; // -->

Israel's military said it killed three militants who crossed into Israel midday near Har Harif with weapons and explosive belts. One soldier from the Israel Defense Forces (IDF) was killed and another wounded in the exchange of fire. The last time an Israeli soldier was killed by militants from the Sinai was August 2011, according to the IDF.

Israel has long been concerned about security in the Sinai peninsula, which it captured in the 1967 Six-Day War but ceded after making peace with Egypt in 1978.

Former Egyptian President Hosni Mubarak's regime responded harshly to terrorist attacks in the peninsula, particularly after a 2004 attack that killed 34 in the tourist city of Taba, as The Christian Science Monitor's Dan Murphy pointed out recently. But with Mr. Mubarak's ouster last year and the formation of a new government dominated by the Islamist Muslim Brotherhood, Israel has voiced concern that Egyptian security in the Sinai has taken a backseat.?

The deterioration in security has been bad for both sides, however. In August, 16 Egyptian border guards and soldiers were killed, which prompted Egyptian President Mohamed Morsi to?summarily dismiss Defense Minister Mohamed Hussein Tantawi and other top military leaders.

Israel has been building an extensive fence along the Sinai border, which is nearing completion. The Israeli soldiers attacked today were guarding a section of this fence. It's not the first time it has been attacked; in June, two militants attacked IDF contractors involved in building the fence, eliciting a strong statement from Israeli Defense Minister Ehud Barak that the new Egyptian president must "swiftly" put an end to attacks from the Sinai.

While many have speculated that the Egypt-Israel peace deal could falter under Islamist rule in Cairo, the Sinai poses a challenge for both nations. If they don't find a way to work together, they both may suffer.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/IF9kC4dO01E/Attempted-attack-on-Israeli-border-highlights-militant-presence-in-Sinai

lisa marie presley florida panthers tannehill joel ward mock draft washington redskins north country

Viruses help MU scientists battle pathogenic bacteria and improve water supply

Viruses help MU scientists battle pathogenic bacteria and improve water supply [ Back to EurekAlert! ] Public release date: 24-Sep-2012
[ | E-mail | Share Share ]

Contact: Tim Wall
walltj@missouri.edu
573-882-3346
University of Missouri-Columbia

Newly developed technique can kill antibiotic-resistant germs

Infectious bacteria received a taste of their own medicine from University of Missouri researchers who used viruses to infect and kill colonies of Pseudomonas aeruginosa, common disease-causing bacteria. The viruses, known as bacteriophages, could be used to efficiently sanitize water treatment facilities and may aid in the fight against deadly antibiotic-resistant bacteria.

"Our experiment was the first to use bacteriophages in conjunction with chlorine to destroy biofilms, which are layers of bacteria growing on a solid surface," said Zhiqiang Hu, associate professor of civil and environmental engineering in MU's College of Engineering. "The advantage to using viruses is that they can selectively kill harmful bacteria. Beneficial bacteria, such as those used to break down wastes in water treatment plants, are largely unaffected. Hence, viruses could be used to get rid of pathogenic bacteria in water filters that would otherwise have to be replaced. They could save taxpayers' money by reducing the cost of cleaning water."

Bacteria can be difficult to kill when they form a biofilm. The outer crust of bacteria in these biofilms can be killed by chlorine, but the inner bacteria are sheltered. Viruses solve this problem because they spread through an entire colony of bacteria. Hu noted that the bacteriophages are easier to create than the enzymes used to attack biofilms. The viruses also are better at targeting specific bacterial species.

Hu, along with MU's recent graduate, Yanyan Zhang, found the greatest success in killing biofilms by using a combination of bacteriophages and chlorine. An initial treatment with viruses followed by chlorine knocked out 97 percent of biofilms within five days of exposure. When used alone, viruses removed 89 percent of biofilms, while chlorine removed only 40 percent.

"The methods we used to kill Pseudomonas aeruginosa could be used against other dangerous bacteria, even those that have developed resistance to antibiotics," said Hu. "Our work opened the door to a new strategy for combating the dangers and costs of bacterial biofilms. The next step is to expand our experiment into a pilot study."

The study "Combined Treatment of Pseudomonas aeruginosa Biofilms with Bacteriophages and Chlorine" has been published in the journal Biotechnology and Bioengineering.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Viruses help MU scientists battle pathogenic bacteria and improve water supply [ Back to EurekAlert! ] Public release date: 24-Sep-2012
[ | E-mail | Share Share ]

Contact: Tim Wall
walltj@missouri.edu
573-882-3346
University of Missouri-Columbia

Newly developed technique can kill antibiotic-resistant germs

Infectious bacteria received a taste of their own medicine from University of Missouri researchers who used viruses to infect and kill colonies of Pseudomonas aeruginosa, common disease-causing bacteria. The viruses, known as bacteriophages, could be used to efficiently sanitize water treatment facilities and may aid in the fight against deadly antibiotic-resistant bacteria.

"Our experiment was the first to use bacteriophages in conjunction with chlorine to destroy biofilms, which are layers of bacteria growing on a solid surface," said Zhiqiang Hu, associate professor of civil and environmental engineering in MU's College of Engineering. "The advantage to using viruses is that they can selectively kill harmful bacteria. Beneficial bacteria, such as those used to break down wastes in water treatment plants, are largely unaffected. Hence, viruses could be used to get rid of pathogenic bacteria in water filters that would otherwise have to be replaced. They could save taxpayers' money by reducing the cost of cleaning water."

Bacteria can be difficult to kill when they form a biofilm. The outer crust of bacteria in these biofilms can be killed by chlorine, but the inner bacteria are sheltered. Viruses solve this problem because they spread through an entire colony of bacteria. Hu noted that the bacteriophages are easier to create than the enzymes used to attack biofilms. The viruses also are better at targeting specific bacterial species.

Hu, along with MU's recent graduate, Yanyan Zhang, found the greatest success in killing biofilms by using a combination of bacteriophages and chlorine. An initial treatment with viruses followed by chlorine knocked out 97 percent of biofilms within five days of exposure. When used alone, viruses removed 89 percent of biofilms, while chlorine removed only 40 percent.

"The methods we used to kill Pseudomonas aeruginosa could be used against other dangerous bacteria, even those that have developed resistance to antibiotics," said Hu. "Our work opened the door to a new strategy for combating the dangers and costs of bacterial biofilms. The next step is to expand our experiment into a pilot study."

The study "Combined Treatment of Pseudomonas aeruginosa Biofilms with Bacteriophages and Chlorine" has been published in the journal Biotechnology and Bioengineering.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-09/uom-vhm092412.php

hurd hurd christopher hitchens ron paul 2012 zynga stock zynga stock sam houston state university

Program Helps Students Express Themselves With Creative Writing

Program Helps Students Express Themselves With Creative Writing

See Scripts ?

826 is the name of a nonprofit organization that works to help students become better writers by thinking creatively. 826 is also the address of the first center where this literary arts program began in two thousand two. Author Dave Eggars and educator Ninive Calegari started the program in California at 826 Valencia Street in San Francisco. It now serves thirty thousand students through writing and tutoring centers in eight American cities. At the front of 826 Valencia is a pirate supply store. Think of the kind of place where Captain Jack Sparrow might shop. Leigh Lehman is the executive director. She says the idea of entering through a pirate store is meant to get students not to think of the place as a school or tutoring center. During the day, teachers bring classes on field trips and volunteers help with writing projects. After school, students come for help with creative writing and their schoolwork. The center is for public school students between six and eighteen years old. Eight twenty-six Valencia is located in a mostly Latino neighborhood. Ms. Lehman says many of the children are from poor immigrant families. Each 826 center has a different theme ? from the pirate store in San Francisco to a store for ?spies? in Chicago. The national chief executive, Gerald Richards, says budget cuts in public schools mean less money for arts education. And as that goes away, he says, so does the ability for students to use their imagination: ?I think there is much more of a focus on science, technology, engineering and math. There?s a lot of a focus on testing and a lot of the teaching that?s going on in schools is focusing on the test and passing the test rather than thinking about how do we get kids to think.? Leigh Lehman says 826 builds confidence. Students can publish and sell their work at places like the pirate supply store and on the Internet. In twenty-ten, the programs across the country published nine hundred forty-four volumes of student writing. Ms. Lehman says students are proud when their writing gets published. One of the students in San Francisco, Sofia Marquez, says ?I get to use my imagination ? that?s why I like writing.? You can watch another video about the program in San Francisco at voaspecialenglish.com. You can also find texts, MP3s and activities to read, listen and learn English. For VOA Special English, I?m Carolyn Presutti.(Adapted from a radio program broadcast 08Dec2011)

Related Posts

You can skip to the end and leave a response. Pinging is currently not allowed.

Source: http://hoctienganh24h.com/program-helps-students-express-themselves-with-creative-writing/

blue moon eddie murphy ann romney marco rubio marco rubio farrah abraham Paul Ryan Speech

সোমবার, ২৪ সেপ্টেম্বর, ২০১২

Researchers develop editing toolkit for customizing zebrafish genomes

ScienceDaily (Sep. 23, 2012) ? Mayo Clinic researchers and an international team of scientists have developed a highly-efficient means of editing zebrafish genomes for research purposes, eliminating a bottleneck that has stymied biomedical scientists from using the fish as a model for human disease.

The details appear online today in the journal Nature.

For many researchers, zebrafish are becoming the model of choice for genetic studies. However, the inability to efficiently target genetic modifications has delayed their use by some. The Mayo team used an improved variant of artificial transcription activator-like effector nucleases, or TALENs, to provide a new approach.

"By using genetic engineering tools called TALENs and synthetic DNA to make defined changes in the genomes of our fish, we are able to make small changes (just a few nucleotides) as well as add a specific sequence for biological gene switch applications," says Stephen Ekker, Ph.D., senior author and head of Mayo's zebrafish core facility. "This is the first time we've been able to make custom changes to the zebrafish genome."

Dr. Ekker says this toolkit opens the door to a range of new experiments in zebrafish, including modeling of human disease by introducing small point mutations, designing regulated gene alleles, and developing classical structure/function experiments using an animal model system.

This new approach has implications for other model systems, including mice, rats, flies and worms, and possible applications in stem cell research.

"To our knowledge, this TALEN toolkit also is the most active described to date," says Dr. Ekker. "This has important implications for the growing TALEN field, whether used in fish or any other cells. We used this higher activity for genome editing applications. We also used it to conduct a series of somatic gene function assessments, opening the door to an array of non-germline experiments in zebrafish."

Other authors include Victoria Bedell, Jarryd Campbell, Tanya Poshusta, Randall Krug, Sumedha Penheiter, Ph.D., Alvin Ma, Ph.D., and Karl Clark, Ph.D., all of Mayo Clinic; Ying Wang, Ph.D., and Jeffrey Essner, Ph.D., of Iowa State University; Colby Starker, Ph.D., Wenfang Tan, Ph.D., Scott Fahrenkrug, Ph.D., Daniel Carlson, Ph.D., and Daniel Voytas, Ph.D., all of the University of Minnesota; and Anskar Y. H. Leung, M.D., Ph.D., of Queen Mary Hospital, Hong Kong.

Support for the research came from the State of Minnesota, the National Institutes of Health, the National Science Foundation, the Research Grant Council of the University of Hong Kong and the Tang King Yin Research Fund.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Mayo Clinic.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Victoria M. Bedell, Ying Wang, Jarryd M. Campbell, Tanya L. Poshusta, Colby G. Starker, Randall G. Krug II, Wenfang Tan, Sumedha G. Penheiter, Alvin C. Ma, Anskar Y. H. Leung, Scott C. Fahrenkrug, Daniel F. Carlson, Daniel F. Voytas, Karl J. Clark, Jeffrey J. Essner, Stephen C. Ekker. In vivo genome editing using a high-efficiency TALEN system. Nature, 2012; DOI: 10.1038/nature11537

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/NY5ZSCdufwk/120923141214.htm

clint eastwood Julian Castro Chris Lighty Blue Moon August 2012 Eddie Murphy Dead michelle obama robin roberts

Baby-Vegan: iflywiththelostboys: If you eat an animal bi-product you should be...

vegasmo:

haiumadbro:

iflywiththelostboys:

If you eat an animal bi-product you should be forced to watch slaughterhouse videos and you should be made to look at endless pictures of battered/murdered/tortured animals. Don?t like it? Don?t eat it. If you can?t even watch what you are doing to another living?

I?ll watch all those videos while eating a pork chop stuffed inside a chicken breast with a side of steak wrapped in bacon and shrimp. Don?t give a fuq

Yeah most rapists and child molesters and murderers all have the same mindset you do. Have fun with that.

Proof to back that ridiculous claim up?

Source: http://haiumadbro.tumblr.com/post/32133849932

Ramadan 2012 Michelle Jenneke News batman joe paterno Colorado Shooting News British Open

Massacre of preachers in Mali sign of broken army

In this Monday, Sept. 17, 2012 photo, children play on the roadside near a canal where two survivors of a Sept. 8 military-led massacre were witnessed being captured by soldiers later that same night, in Kourouma, Mali. Local resident Souma Diallo saw soldiers capturing an unidentified elderly man with a beard and Moctar Bechir, a minibus driver he recognized. The whereabouts of both men remain unknown. On Sept. 8 in the central Malian village of Diabaly, 1.2 miles (2 kms) from Kourouma, Malian soldiers stopped a minibus in which at least 17 Muslim preachers were traveling to a religious conference in Bamako. Within 1? hours of the car arriving at the checkpoint, 16 of the 17 men were dead.(AP Photo/Rukmini Callimachi)

In this Monday, Sept. 17, 2012 photo, children play on the roadside near a canal where two survivors of a Sept. 8 military-led massacre were witnessed being captured by soldiers later that same night, in Kourouma, Mali. Local resident Souma Diallo saw soldiers capturing an unidentified elderly man with a beard and Moctar Bechir, a minibus driver he recognized. The whereabouts of both men remain unknown. On Sept. 8 in the central Malian village of Diabaly, 1.2 miles (2 kms) from Kourouma, Malian soldiers stopped a minibus in which at least 17 Muslim preachers were traveling to a religious conference in Bamako. Within 1? hours of the car arriving at the checkpoint, 16 of the 17 men were dead.(AP Photo/Rukmini Callimachi)

In this Monday, Sept. 17, 2012 photo, children play on the roadside near a canal where two survivors of a Sept. 8 military-led massacre were witnessed being captured by soldiers later that same night, in Kourouma, Mali. Local resident Souma Diallo saw soldiers capturing an unidentified elderly man with a beard and Moctar Bechir, a minibus driver he recognized. The whereabouts of both men remain unknown. On Sept. 8 in the central Malian village of Diabaly, 1.2 miles (2 kms) from Kourouma, Malian soldiers stopped a minibus in which at least 17 Muslim preachers were traveling to a religious conference in Bamako. Within 1? hours of the car arriving at the checkpoint, 16 of the 17 men were dead.(AP Photo/Rukmini Callimachi)

In this Thursday, Sept. 20, 2012 photo, Maouloud Ould Sidi Mohamed, the sole known survivor of a military-led massacre in central Mali, shows the gashes on his feet, sustained as he hid in the forest for five days, at the Mauritanian Embassy in Bamako, Mali. On the night of Sept. 8, Malian soldiers opened fire on the car in which at least 17 Muslim preachers, nine of whom, including Mohamed, were from neighboring Mauritania, were traveling to a religious conference in Bamako. Within 1? hours of the car being stopped by soldiers, 16 of the 17 men were dead. Mohamed managed to hide between the cadavers in the bed of the truck, and then to escape, losing his shoes as he fled. He was eventually recaptured by Malian soldiers and held for a week before being released to the Mauritanian embassy for repatriation following intense diplomatic pressure. (AP Photo/Rukmini Callimachi)

In this Monday, Sept. 17, 2012 photo, children play on the roadside in front of the military camp where 16 Muslim preachers were executed by Malian security forces on the night of Sept. 8, in the village of Diabaly in central Mali. An investigation by The Associated Press found that rank-and-file soldiers carried out the massacre of their own accord, ignoring not only the normal rules of engagement but also their own command structure. Their actions show just how much the military of this once-stable nation has broken down since a coup six months ago, with officers no longer able to control their troops. (AP Photo/Rukmini Callimachi)

In this Wednesday, Sept. 19, 2012 photo, ID cards from some of the 16 Muslim preachers killed in a Sept. 8 military-led massacre in central Mali, are pictured in Bamako, Mali. An investigation by The Associated Press found that rank-and-file soldiers carried out the massacre of their own accord, ignoring not only the normal rules of engagement but also their own command structure. Their actions show just how much the military of this once-stable nation has broken down since a coup six months ago, with officers no longer able to control their troops.(AP Photo/Rukmini Callimachi)

(AP) ? It was dusk when the aging Toyota pickup truck pulled into the first military checkpoint, loaded with at least 17 bearded men fingering prayer beads.

This pinprick of a village in central Mali is not even large enough to appear on most administrative maps. Cars pass through here so rarely that donkeys fall asleep in the center of the highway.

The preachers were coming from Mauritania and had paperwork showing they were on their way to a religious conference in Mali's capital, 270 miles (430 kilometers) away. None of them was armed.

Soldiers arrested them and brought them to a military camp. There they opened fire on the stationary truck, spraying it with their machine guns. Then they dragged out the corpses, buried them in a mass grave and launched a manhunt for those who had escaped.

Within 1? hours of the car arriving at the checkpoint, 16 of the 17 men were dead.

The AP has found that rank-and-file soldiers carried out the massacre of their own accord, ignoring not only the normal rules of engagement but also their own command structure. Their actions show just how much the military of this once-stable nation has broken down since a coup six months ago, with officers no longer able to control their troops.

These concerns about Mali's military come at a time when the world is considering sending arms, equipment and troops to help it take back the north, which has fallen to Islamic extremists. Just this week, the United Nations Security Council instructed Mali's neighbors to submit a detailed plan for military intervention, which the U.N. would support.

"It's as if Mali has fallen into a coma," said analyst Gilles Yabi, the West Africa director for the International Crisis Group and author of a recent report on this troubled country. "The reality on the ground is that it's the rank-and-file soldiers that are now in power. ... And it's in this context that you can explain such a grave blunder as what we saw happen in Diabaly."

Mali is a country of 15.8 million people that is turning into an ungoverned vaccuum, a source of increasing worry for the rest of the world. It's been exactly six months since junior officers overthrew the democratically elected government on March 22. In the wake of the coup, rebels allied with al-Qaida seized control of the north, creating a new haven for extreme Islam.

It was into this turmoil that the group of preachers stumbled, at around 7 p.m. on the night of Sept. 8. The AP has pieced their story together through interviews with the one known survivor, two police officers present at the time of the attack and their superior, diplomats, villagers, and family members in Mauritania, who prepared their bullet-riddled bodies for burial.

The Toyota minibus with plate No. 0148AN00 RIM rolled in just as dark was enveloping the bridge at Dogofri, nine miles (15 kilometers) north of Diabaly. Anyone in these parts would have recognized the letters RIM as standing for Republique Islamique de la Mauritanie, or Mauritania, Mali's more religious neighbor to the north.

The preachers included at least nine Mauritanians and seven Malians, ranging in age from 25 to 54. They belonged to the Dawa Tablighi, a fundementalist but non-violent current of Islam.

The Mali military had been instructed to monitor members of the sect, especially those trying to enter from neighboring countries, according to an internal memo dated Sept. 5, seen by Amnesty International.

"In view of the situation in the north of the country," the memo from the Department of Home and Security said, "It seems appropriate to consider steps to better marshal this association, particularly with regard to foreign participants, in order to limit their entry into the national territory."

The preachers met up in Fassala, a town at the Mauritanian border.

Two of them had tried to come to Mali in July but had been turned back. So to make sure they wouldn't have any problems, they hired Moctar Bechir, a Malian truck driver who frequently transports merchandise from Mauritania to Mali.

On Sept. 8, the truck had already been rented by a wholesaler transporting about a ton of beans. The preachers sat squished together in the cab and on top of the sacks of beans, said 51-year-old Maouloud Ould Sidi Mohamed, the sole confirmed survivor of the massacre, in an exclusive interview with The Associated Press.

The preachers were stopped at the entrance to Dogofri, where police checked their identity cards and asked questions. The paramilitary police, or gendarmes, wrote down the list of names in a register, a copy of which the AP saw.

They were stopped again at the bridge, this time by the military. That's when the trouble started.

"There was a young man with us, Amane. He has a really nice beard," said Mohamed. "When they saw him, they got suspicious."

They sent the men inside and searched the car. All they found, Mohamed said, was a couple of pots.

Then they started to interrogate the preachers, one by one. They opened one man's bag, and found clothes and a bar of soap. Then they put the men back in the Toyota and drove them to Diabaly, in a caravan between two pickup trucks mounted with machine guns.

When they saw what the soldiers were doing, the gendarmes radioed their commander. He instructed them to send one police officer to follow the convoy on his scooter. All the gendarmes who spoke to the AP requested anonymity out of fear for their safety.

It takes less than 20 minutes to drive from Dogofri to Diabaly, a nine-mile-long dirt road of red earth beaten down by the tires of lorries. The road is lined by rice paddies on the left and a tributary of the Niger River on the right.

On that evening, like on every other, women bathed in the river topless and laid their laundry to dry out on the rocky ground. Just about the loudest sound on any normal night is the high-pitched braying of a donkey.

When the caravan arrived at the camp, the gendarme and the soldiers in the two accompanying cars went into the commander's office. Just 15 minutes later, the shooting erupted.

The gendarme ran back out and saw bodies lying on the ground. He called his superior to say the soldiers were killing the preachers. The senior officer confirmed to the AP that he received the call between 8 and 9 p.m.

"It's due to the indiscipline inside the army," said the senior officer. "The night that this happened, everyone knows which soldiers were on duty. They decided themselves, without being given an order, and without consulting with their higher-ups to do this."

The survivor, Mohamed, said the men in the truck could hear the soldiers discussing what to do with them.

"I don't think my friends could have imagined what was about to happen," said Mohamed. "But I knew. I know this country. And I understood that it was over for us."

When the shooting suddenly started, Mohamed saw people falling around him. He himself fell and hid between the cadavers in the bed of the truck.

A few moments later, he saw two people try to run. He followed them out of the car, crawling between the wheels of the lorry.

He reached a small wall. While climbing it, he lost his shoe. So he left the other one behind, ran barefoot across the rice paddies and jumped into a canal. His robe hung heavy with water, so he took it off. He swam in his underwear and undershirt.

On the other side, he hid by some trees. He says he saw the light from the torches of the soldiers looking for him.

He hid for five days. On the night of Sept. 13, they found him and took him back to the camp.

Mohamed was held by the military incommunicado for a week. He was transfered from Diabaly to a garrison in the capital, Bamako, where he was kept under constant watch. He was too afraid to even speak with an envoy from the Mauritanian embassy.

He was released this Thursday after immense diplomatic pressure, and spoke to the AP inside the Mauritanian embassy in the minutes before he was whisked off to the airport. Both Malian and Mauritanian officials confirmed his identity. The soles of his feet were pockmarked by gashes after five days of walking without shoes.

If you follow the red dirt highway another 1.2 miles (2 kilometers) south, you reach the village of Kourouma. Souma Diallo, a 40-year-old machine operator, was getting ready to go to sleep at around midnight on Sept. 8 when he heard people shouting.

He stepped out and saw the soldiers had caught an old man with a long beard. His hands were tied with his own turban. The man's whereabouts remain unknown.

Diallo also saw a young man who was bleeding from his head. It was the truck driver, Moctar Bechir ? whom Diallo recognized because both have extended family in nearby Niono. Diallo told the soldiers he knew the young man, handed over his phone and asked the driver to call people who could confirm his identity.

A few days later, on Sept. 12, the soldiers returned to Diallo's home and arrested him, he said. They accused him of complicity "with the rebels."

They brought him to the camp and started screaming at him. The soldiers had blood-shot eyes, like they were drugged, he said. When they briefly left him alone, Diallo bolted, crawled through a hole in a wall and ran for his life.

Behind the kitchen, he came face-to-face with the driver, Bechir. He was tied to a bench with a rope around his waist. They said nothing to each other.

Diallo spoke to the AP from his hiding place in a different part of Mali on the condition that his whereabouts not be disclosed.

In the days after the shooting, nine bodies with multiple bullet wounds were repatriated to Mauritania. Seven were buried in a municipal cemetery in Bamako. Mali issued a government communique expressing deep condolences, but stopping short of taking responsibility for the deaths.

Col. Idrissa Traore, director of public relations for the Malian military, acknowledged that the troops at Diabaly had violated the command structure. But he noted that the preachers came from the former sect of Iyad Ag Ghali, the head of one extremist group now controlling Mali's north.

Traore said the military had kept Mohamed for a week because he was "in a bad psychological state," and they wanted to question him.

"An investigation is in process to determine all of this. And once we are done, we will make a declaration," he said.

Representatives of the families of the dead have met with the minister of defense. He denied knowing anything about the driver.

Hassane Bechir, the 44-year-old brother of the driver, now spends his days waiting inside a room in Bamako. He smokes cigarettes, his dull eyes watching the passing images on a television a few feet away.

"So long as I don't have proof that he is dead, then to me, he is alive," said the missing man's older brother. "They haven't given me a body. At the very least, give me his body."

__

Associated Press writer Baba Ahmed contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-09-22-Mali-A%20Small%20Town%20Shooting/id-e8bc11f09c114c8eb6dac1b46c68a653

st louis blues rueben randle mike trout ryan broyles jerel worthy alshon jeffery miami heat